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Publications including work performed on the Genomics Platform
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C.R. Cederroth, C. Zimmermann, J.-L. Bény, O. Schaad, C. Combépine, P. Descombes, D.R. Doerge, F.P. Pralong, J.-D. Vassalli and S. Nef S (2010).
Potential detrimental effects of a phytoestrogen-rich diet on male fertility in mice.
Molecular and Cellular Endocrinology 321, 152-160.
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R. De Cegli, A. Romito, S. Iacobacci, L. Mao, M. Lauria, A.O. Fedele, J. Klose, C. Borel, P. Descombes, S.E. Antonarakis, D. di Bernardo, S. Banfi, A. Ballabio and G. Cobellis (2010).
A mouse embryonic stem cell bank for inducible overexpression of human chromosome 21 genes.
Genome Biology 11: R64.
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L. Gruaz, C. Delucinge-Vivier, P. Descombes, J.-M. Dayer and D. Burger (2010).
Blockade of T cell contact-activation of human monocytes by high-density lipoproteins reveals a new pattern of cytokine and inflammatory genes.
PLoS One 5, e9418.
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N.C. Hübner, L.H. Wang, M. Kaulich, P. Descombes, I. Poser and E.A. Nigg (2010).
Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs.
Chromosoma 119, 149-165.
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R. Lubomirov, J. di Iulio, A. Fayet, S. Colombo, R. Martinez, C. Marzolini, H. Furrer, P. Vernazza, A. Calmy, M. Cavassini, B. Ledergerber, K. Rentsch, P. Descombes, T. Buclin, L.A. Decosterd, C. Csajka, A. Telenti and the Swiss HIV Cohort Study (2010).
ADME pharmacogenetics: investigation of the pharmacokinetics of the antiretroviral agent lopinavir coformulated with ritonavir.
Pharmacogenetics and Genomics 20, 217-230.
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M.D. Papaioannou, M. Lagarrigue, C.E. Vejnar, A.D. Rolland, F. Kühne, F. Aubry, O. Schaad, A. Fort, P. Descombes, M. Neerman-Arbez, F. Guillou, E.M. Zdobnov, C. Pineau and S. Nef (2010).
Loss of Dicer in Sertoli cells has a major impact on the testicular proteome of mice.
Molecular and Cellular Proteomics. E-pub ahead of print.
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A. Rauch, Z. Kutalik, P. Descombes, T. Cai, J. di Iulio, T. Mueller, M. Bochud, M. Battegay, E. Bernasconi, J. Borovicka, S. Colombo, A. Cerny, J.-F. Dufour, H. Furrer, H.F. Günthard, M. Heim, B. Hirschel, R. Malinverni, D. Moradpour, B. Müllhaupt, A. Witteck, J.S. Beckmann, T. Berg, S. Bergmann, F. Negro, A. Telenti, P.-Y. Bochud, the Swiss Hepatitis C Cohort Study and the Swiss HIV Cohort Study (2010).
Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study.
Gastroenterology 138, 1338-1345.e7.
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M. Rotger, K.K. Dang, J. Fellay, E.L. Heinzen, S. Feng, P. Descombes, K.V. Shianna, D. Ge, H.F. Günthard, D.B. Goldstein, A. Telenti, the Swiss HIV Cohort Study and the Center for HIV⁄AIDS Vaccine Immunology (2010).
Genome-wide mRNA expression correlates of viral control in CD4+ T-cells from HIV-1-infected individuals.
PLoS Pathogens 6, e1000781.
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C. Yokthongwattana, E. Bucher, M. Caikovski, I. Vaillant, J. Nicolet, O. Mittelsten Scheid and J. Paszkowski (2010).
MOM1 and Pol-IV⁄V interactions regulate the intensity and specificity of transcriptional gene silencing.
The EMBO Journal 29, 340-351.
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E.N. Bianchi and S.L. Ferrari (2009).
ß-arrestin2 regulates parathyroid hormone effects on a p38 MAPK and NFκB gene expression network in osteoblasts.
Bone 45, 716-725.
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J. Fellay, D. Ge, K.V. Shianna, S. Colombo, B. Ledergerber, E.T. Cirulli, T.J. Urban, K. Zhang, C.E. Gumbs, J.P. Smith, A. Castagna, A. Cozzi-Lepri, A. De Luca, P. Easterbrook, H.F. Günthard, S. Mallal, C. Mussini, J. Dalmau, J. Martinez-Picado, J.M. Miro, N. Obel, S.M. Wolinsky, J.J. Martinson, R. Detels, J.B. Margolick, L.P. Jacobson, P. Descombes, S.E. Antonarakis, J.S. Beckmann, S.J. O’Brien, N.L. Letvin, A.J. McMichael, B.F. Haynes, M. Carrington, S. Feng, A. Telenti, D.B. Goldstein and the NIAID Center for HIV⁄AIDS Vaccine Immunology (CHAVI) (2009).
Common genetic variation and the control of HIV-1 in humans.
PLoS Genetics 5, e1000791.
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C.G. Geoffroy, J.A. Critchley, D.S. Castro, S. Ramelli, C. Barraclough, P. Descombes, F. Guillemot and O. Raineteau (2009).
Engineering of dominant active basic helix-loop-helix proteins that are resistant to negative regulation by postnatal central nervous system antineurogenic cues.
Stem Cells 27, 847-856.
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J. Iff, W. Wang, T. Sajic, N. Oudry, E. Gueneau, G. Hopfgartner, E. Varesio and I. Szanto (2009).
Differential proteomic analysis of STAT6 knockout mice reveals new regulatory function in liver lipid homeostasis.
Journal of Proteome Research 8, 4511-4524.
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G. Le Martelot, T. Claudel, D. Gatfield, O. Schaad, B. Kornmann, G.L. Sasso, A. Moschetta and U. Schibler (2009).
REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis.
PLoS Biology 7, e1000181.
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S.I. Nikolaev, S. Deutsch, R. Genolet, C. Borel, L. Parand, C. Ucla, F. Schütz, G. Duriaux Sail, Y. Dupré, P. Jaquier-Gubler, T. Araud, B. Conne, P. Descombes, J.-D. Vassalli, J. Curran and S.E. Antonarakis (2009).
Transcriptional and post-transcriptional profile of human chromosome 21.
Genome Research 19, 1471-1479.
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D.P. Pandey and D. Picard (2009).
miR-22 Inhibits estrogen signaling by directly targeting the estrogen receptor α mRNA.
Molecular and Cellular Biology 29, 3783-3790.
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D.P. Pandey, R. Lappano, L. Albanito, A. Madeo, M. Maggiolini and D. Picard (2009).
Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF.
The EMBO Journal 28, 523-532.
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M.D. Papaioannou, J.-L. Pitetti, S. Ro, C. Park, F. Aubry, O. Schaad, C.E. Vejnar, F. Kühne, P. Descombes, E.M. Zdobnov, M.T. McManus, F. Guillou, B.D. Harfe, W. Yan, B. Jégou B and S. Nef (2009).
Sertoli cell Dicer is essential for spermatogenesis in mice.
Developmental Biology 386, 250-259.
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V. Pazienza, S. Clément, P. Pugnale, S. Conzelmann, S. Pascarella, A. Mangia and F. Negro (2009).
Gene expression profile of Huh-7 cells expressing hepatitis C virus genotype 1b or 3a core proteins.
Liver International 29, 661-669.
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P. Pugnale, V. Pazienza, K. Guilloux and F. Negro (2009).
Hepatitis delta virus inhibits alpha interferon signaling.
Hepatology 49, 398-406.
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J.M. Ramirez, O. Schaad, S. Durual, D. Cossali, M. Docquier, P. Beris, P. Descombes and T. Matthes (2009).
Growth differentiation factor 15 production is necessary for normal erythroid differentiation and is increased in refractory anaemia with ring-sideroblasts.
British Journal of Haematology 144, 251-262.
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J. Reinders, B.B.H. Wulff, M. Mirouze, A. Marí-Ordóñez, M. Dapp, W. Rozhon, E. Bucher, G. Theiler and J. Paszkowski (2009).
Compromised stability of DNA methylation and transposon immobilization in mosaic Arabidopsis epigenomes.
Genes and Development 23, 939-950.
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D. Skowronska-Krawczyk, F. Chiodini, M. Ebeling, C. Alliod, A. Kundzewicz, D. Castro, M. Ballivet, F. Guillemot, L. Matter-Sadzinski, J.-M. Matter (2009).
Conserved regulatory sequences in Atoh7 mediate non-conserved regulatory responses in retina ontogenesis.
Development 136, 3767-3777.
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N. Soshnikova and D. Duboule (2009).
Epigenetic temporal control of mouse Hox genes in vivo.
Science 324, 1320-1323.
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A. Taddei, G. Van Houwe, S. Nagai, I. Erb, E. Van Nimwegen and S.M. Gasser (2009).
The functional importance of telomere clustering: global changes in gene expression result from SIR factor dispersion.
Genome Research 19, 611-625.
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M. Vinciguerra, A. Sgroi, C. Veyrat-Durebex, L. Rubbia-Brandt, L.H. Buhler and M. Foti (2009).
Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes.
Hepatology 49, 1176-1184.
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S.-J. Zhang, M. Zou, L. Lu, D. Lau, D.A.W. Ditzel, C. Delucinge-Vivier, Y. Aso, P. Descombes and H. Bading (2009).
Nuclear calcium signaling controls expression of a large gene pool: identification of a gene program for acquired neuroprotection induced by synaptic activity.
PLoS Genetics 5, e1000604.
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J. Bonnefont, S.I. Nikolaev A.L. Perrier, S. Guo, L. Cartier, S. Sorce, T. Laforge, L. Aubry, P. Khaitovich, M. Peschanski, S.E. Antonarakis and K.-H. Krause (2008).
Evolutionary forces shape the human RFPL1,2,3 genes toward a role in neocortex development.
American Journal of Human Genetics 83, 208-218.
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C.R. Cederroth, M. Vinciguerra, A. Gjinovci, F. Kühne, M. Klein, M. Cederroth, D. Caille, M. Suter, D. Neumann, R.W. James, D.R. Doerge, T. Wallimann, P. Meda, M. Foti, F. Rohner-Jeanrenaud, J.-D. Vassalli and S. Nef (2008).
Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism.
Diabetes 57, 1176-1185.
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S. Clément, C. Juge-Aubry, A. Sgroi, S. Conzelmann, V. Pazienza, B. Pittet-Cuenod, C.A. Meier and F. Negro (2008).
Monocyte chemoattractant protein-1 secreted by adipose tissue induces direct lipid accumulation in hepatocytes.
Hepatology 48, 799-807.
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S. Fokstuen, R. Lyle, A. Munoz, C. Gehrig, R. Lerch, A. Perrot, K.J. Osterziel, C. Geier, M. Beghetti, F. Mach, J. Sztajzel, U. Sigwart, S.E. Antonarakis and J.-L. Blouin (2008).
A DNA resequencing array for pathogenic mutation detection in hypertrophic cardiomyopathy.
Human Mutation 29, 879-885.
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M. Friedli, S. Nikolaev, R. Lyle, M. Arcangeli, D. Duboule, F. Spitz and S.E. Antonarakis (2008).
Characterization of mouse Dactylaplasia mutations: a model for human ectrodactyly SHFM3.
Mammalian Genome 19, 272-278.
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D. Grégoire and M. Kmita (2008).
Recombination between inverted loxP sites is cytotoxic for proliferating cells and provides a simple tool for conditional cell ablation.
PNAS 105, 14492-14496.
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S. Hayoz, R. Bychkov, K. Serir, M. Docquier and J.-L. Bény (2008).
Purinergic activation of a leak potassium current in freshly dissociated myocytes from mouse thoracic aorta.
Acta Physiologica 195, 247-258.
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N. Hoecker, B. Keller, N. Muthreich, D. Chollet, P. Descombes, H.P. Piepho and F. Hochholdinger (2008).
Comparison of maize (Zea mays L.) F1-hybrid and parental inbred line primary root transcriptomes suggests organ-specific patterns of nonadditive gene expression and conserved expression trends.
Genetics 179, 1275-1283.
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M. Krawczyk, Q. Seguín-Estévez, E. Leimgruber, P. Sperisen, C. Schmid, P. Bucher and W. Reith (2008).
Identification of CIITA regulated genetic module dedicated for antigen presentation.
PLoS Genetics 4, e1000058.
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T. Montavon, J.-F. Le Garrec, M. Kerszberg and D. Duboule (2008).
Modeling Hox gene regulation in digits: reverse collinearity and the molecular origin of thumbness.
Genes and Development 22, 346-359.
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A. Murat, E. Migliavacca, T. Gorlia, W.L. Lambiv, T. Shay, M.-F. Hamou, N. de Tribolet, L. Regli, W. Wick, M.C.M. Kouwenhoven, J.A. Hainfellner, F.L. Heppner, P.-Y. Dietrich, Y. Zimmer, J.G. Cairncross, R.-C. Janzer, E. Domany, M. Delorenzi, R. Stupp and M.E. Hegi (2008).
Stem cell-related “self-renewal” signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma.
Journal of Clinical Oncology 26, 3015-3024.
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J. Reinders, C. Delucinge Vivier, G. Theiler, D. Chollet, P. Descombes and J. Paszkowski (2008).
Genome-wide, high-resolution DNA methylation profiling using bisulfite-mediated cytosine conversion.
Genome Research 18, 469-476.
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D.F. Simon, P. Descombes, W. Zerges and K.J. Wilkinson (2008).
Global expression profiling of Chlamydomonas reinhardtii exposed to trace levels of free cadmium.
Environmental Toxicology and Chemistry 27, 1668-1675.
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O. Sorg, C. Tran, P. Carraux, D. Grand, C. Barraclough, J.-F. Arrighi, P. Descombes, V. Piguet and J.-H. Saurat (2008).
Metabolism and biological activities of topical 4-oxoretinoids in mouse skin.
Journal of Investigative Dermatology 128, 999-1008.
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A. Spierer, F. Begeot, P. Spierer and M. Delattre (2008).
SU(VAR)3-7 links heterochromatin and dosage compensation in Drosophila.
PLoS Genetics 4, e1000066.
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M. Vinciguerra, C. Veyrat-Durebex, M.A. Moukil, L. Rubbia-Brandt, F. Rohner-Jeanrenaud and M. Foti (2008).
PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-κBp65/mTOR-dependent mechanism.
Gastroenterology 134, 268-280.
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