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Selected publications since 2008
2010
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Aegerter-Wilmsen T, Smith AC, Christen AJ, Aegerter CM, Hafen E, Basler K (2010).
Exploring the effects of mechanical feedback on epithelial topology.
Development 137(3):499-506.
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Ahrens CH, Brunner E, Basler K (2010).
Quantitative proteomics: a central technology for systems biology.
J Proteomics 73(4):820-7.
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Antonarakis SE, Chakravarti A, Cohen JC, Hardy J (2010).
Mendelian disorders and multifactorial traits: the big divide or one for all?
Nat Rev Genet 11(5):380-4.
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Busskamp V, Duebel J, Balya D, Fradot M, Viney TJ, Siegert S, Groner AC, Cabuy E, Forster V, Seeliger M, Biel M, Humphries P, Paques M, Mohand-Said S, Trono D, Deisseroth K, Sahel JA, Picaud S, Roska B (2010).
Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa.
Science 329(5990):413-7.
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De Cegli R, Romito A, Iacobacci S, Mao L, Lauria M, Fedele AO, Klose J, Borel C, Descombes P, Antonarakis SE, di Bernardo D, Banfi S, Ballabio A, Cobellis G (2010).
A mouse embryonic stem cell bank for inducible overexpression of human chromosome 21 genes.
Genome Biol 11(6):R64.
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Di-Poï N, Koch U, Radtke F, Duboule D (2010).
Additive and global functions of HoxA cluster genes in mesoderm derivatives.
Dev Biol 341(2):488-98.
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Di-Poï N, Montoya-Burgos JI, Miller H, Pourquié O, Milinkovitch MC, Duboule D (2010).
Changes in Hox genes’ structure and function during the evolution of the squamate body plan.
Nature 464(7285):99-103.
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Groner AC, Meylan S, Ciuffi A, Zangger N, Ambrosini G, Dénervaud N, Bucher P, Trono D (2010).
KRAB-zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading.
PLoS Genet 6(3):e1000869.
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Krol J, Busskamp V, Markiewicz I, Stadler MB, Ribi S, Richter J, Duebel J, Bicker S, Fehling HJ, Schübeler D, Oertner TG, Schratt G, Bibel M, Roska B, Filipowicz W (2010).
Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs.
Cell 141(4):618-31.
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Maillard PV, Ecco G, Ortiz M, Trono D (2010).
The specificity of TRIM5 alpha-mediated restriction is influenced by its coiled-coil domain.
J Virol 84(11):5790-801.
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Massouras A, Decouttere F, Hens K, Deplancke B (2010).
WebPrInSeS: automated full-length clone sequence identification and verification using high-throughput sequencing data.
Nucleic Acids Res 38 Suppl:W378-84.
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Massouras A, Hens K, Gubelmann C, Uplekar S, Decouttere F, Rougemont J, Cole ST, Deplancke B (2010).
Primer-initiated sequence synthesis to detect and assemble structural variants.
Nat Methods 7(7):485-6.
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Montgomery SB, Sammeth M, Gutierrez-Arcelus M, Lach RP, Ingle C, Nisbett J, Guigo R, Dermitzakis ET (2010).
Transcriptome genetics using second generation sequencing in a Caucasian population.
Nature 464(7289):773-7.
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Nica AC, Montgomery SB, Dimas AS, Stranger BE, Beazley C, Barroso I, Dermitzakis ET (2010).
Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.
PLoS Genet 6(4):e1000895.
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Rodriguez I (2010).
The chemical MUPpeteer.
Cell 141(4):568-70.
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Rowe HM, Jakobsson J, Mesnard D, Rougemont J, Reynard S, Aktas T, Maillard PV, Layard-Liesching H, Verp S, Marquis J, Spitz F, Constam DB, Trono D (2010).
KAP1 controls endogenous retroviruses in embryonic stem cells.
Nature 463(7278):237-40.
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Schwank G, Basler K (2010).
Regulation of organ growth by morphogen gradients.
Cold Spring Harb Perspect Biol 2(1):a001669.
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Sharp AJ, Migliavacca E, Dupre Y, Stathaki E, Sailani MR, Baumer A, Schinzel A, Mackay DJ, Robinson DO, Cobellis G, Cobellis L, Brunner HG, Steiner B, Antonarakis SE (2010).
Methylation profiling in individuals with uniparental disomy identifies novel differentially methylated regions on chromosome 15.
Genome Res. E-pub ahead of print.
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Simicevic J, Deplancke B (2010).
DNA-centered approaches to characterize regulatory protein-DNA interaction complexes.
Mol Biosyst 6(3):462-8.
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Song H, Goetze S, Bischof J, Spichiger-Haeusermann C, Kuster M, Brunner E, Basler K (2010).
Coop functions as a corepressor of Pangolin and antagonizes Wingless signaling.
Genes Dev 24(9):881-6.
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The International HapMap 3 Consortium; Principal investigators, Altshuler DM, Gibbs RA, Peltonen L; Project coordination leaders, Altshuler DM, Gibbs RA, Peltonen L, Dermitzakis E (2010).
Integrating common and rare genetic variation in diverse human populations.
Nature 467(7311):52-58.
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Trono D, Van Lint C, Rouzioux C, Verdin E, Barré-Sinoussi F, Chun TW, Chomont N (2010).
HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals.
Science 329(5988):174-80.
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Villavicencio-Lorini P, Kuss P, Friedrich J, Haupt J, Farooq M, Türkmen S, Duboule D, Hecht J, Mundlos S (2010).
Homeobox genes d11-d13 and a13 control mouse autopod cortical bone and joint formation.
J Clin Invest 120(6):1994-2004.
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Woltering JM, Duboule D (2010).
The origin of digits: expression patterns versus regulatory mechanisms.
Dev Cell 18(4):526-32.
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2009
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Barde I, Laurenti E, Verp S, Groner AC, Towne C, Padrun V, Aebischer P, Trumpp A, Trono D (2009).
Regulation of episomal gene expression by KRAB⁄KAP1-mediated histone modifications.
J Virol 83(11):5574-80.
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Bedard K, Attar H, Bonnefont J, Jaquet V, Borel C, Plastre O, Stasia MJ, Antonarakis SE, Krause KH (2009).
Three common polymorphisms in the CYBA gene form a haplotype associated with decreased ROS generation.
Hum Mutat 30(7):1123-33.
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Boldogkoi Z, Balint K, Awatramani GB, Balya D, Busskamp V, Viney TJ, Lagali PS, Duebel J, Pásti E, Tombácz D, Tóth JS, Takács IF, Scherf BG, Roska B (2009).
Genetically timed, activity-sensor and rainbow transsynaptic viral tools.
Nat Methods 6(2):127-30.
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Bulliard Y, Turelli P, Röhrig UF, Zoete V, Mangeat B, Michielin O, Trono D (2009).
Functional analysis and structural modeling of human APOBEC3G reveal the role of evolutionarily conserved elements in the inhibition of human immunodeficiency virus type 1 infection and Alu transposition.
J Virol 83(23):12611-21.
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Capello L, Roppolo D, Jungo VP, Feinstein P, Rodriguez I (2009).
A common gene exclusion mechanism used by two chemosensory systems.
Eur J Neurosci 29(4):671-8.
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Deplancke B (2009).
Experimental advances in the characterization of metazoan gene regulatory networks.
Brief Funct Genomic Proteomic 8(1):12-27.
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Dermitzakis ET, Clark AG (2009).
Genetics. Life after GWA studies.
Science 326(5950):239-40.
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D’haene B, Attanasio C, Beysen D, Dostie J, Lemire E, Bouchard P, Field M, Jones K, Lorenz B, Menten B, Buysse K, Pattyn F, Friedli M, Ucla C, Rossier C, Wyss C, Speleman F, De Paepe A, Dekker J, Antonarakis SE, De Baere E (2009).
Disease-causing 7.4 kb cis-regulatory deletion disrupting conserved non-coding sequences and their interaction with the FOXL2 promotor: implications for mutation screening.
PLoS Genet 5(6):e1000522.
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Dimas AS, Dermitzakis ET (2009).
Genetic variation of regulatory systems.
Curr Opin Genet Dev 19(6):586-90.
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Dimas AS, Deutsch S, Stranger BE, Montgomery SB, Borel C, Attar-Cohen H, Ingle C, Beazley C, Gutierrez Arcelus M, Sekowska M, Gagnebin M, Nisbett J, Deloukas P, Dermitzakis ET, Antonarakis SE (2009).
Common regulatory variation impacts gene expression in a cell type-dependent manner.
Science 325(5945):1246-50.
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Duboule D (2009).
The Hox complex - an interview with Denis Duboule. Interviewed by Richardson, Michael K.
Int J Dev Biol 53(5-6):717-23.
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Fellay J, Ge D, Shianna KV, Colombo S, Ledergerber B, Cirulli ET, Urban TJ, Zhang K, Gumbs CE, Smith JP, Castagna A, Cozzi-Lepri A, De Luca A, Easterbrook P, Günthard HF, Mallal S, Mussini C, Dalmau J, Martinez-Picado J, Miro JM, Obel N, Wolinsky SM, Martinson JJ, Detels R, Margolick JB, Jacobson LP, Descombes P, Antonarakis SE, Beckmann JS, O’Brien SJ, Letvin NL, McMichael AJ, Haynes BF, Carrington M, Feng S, Telenti A, Goldstein DB; NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI) (2009).
Common genetic variation and the control of HIV-1 in humans.
PLoS Genet 5(12):e1000791.
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Gatfield D, Le Martelot G, Vejnar CE, Gerlach D, Schaad O, Fleury-Olela F, Ruskeepää A-L, Oresic M, Esau CC, Zdobnov EM, Schibler U (2009).
Integration of microRNA miR-122 in hepatic circadian gene expression.
Genes Dev 23(11):1313-26.
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Geuking P, Narasimamurthy R, Lemaitre B, Basler K, Leulier F (2009).
A non-redundant role for Drosophila Mkk4 and hemipterous⁄Mkk7 in TAK1-mediated activation of JNK.
PLoS One 4(11):e7709.
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Goetze S, Qeli E, Mosimann C, Staes A, Gerrits B, Roschitzki B, Mohanty S, Niederer EM, Laczko E, Timmerman E, Lange V, Hafen E, Aebersold R, Vandekerckhove J, Basler K, Ahrens CH, Gevaert K, Brunner E (2009).
Identification and functional characterization of N-terminally acetylated proteins in Drosophila melanogaster.
PLoS Biol 7(11):e1000236.
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Grobei MA, Qeli E, Brunner E, Rehrauer H, Zhang R, Roschitzki B, Basler K, Ahrens CH, Grossniklaus U (2009).
Deterministic protein inference for shotgun proteomics data provides new insights into Arabidopsis pollen development and function.
Genome Res 19(10):1786-800.
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Hamaratoglu F, Basler K, Affolter M (2009).
Confronting morphogen gradients: how important are they for growth?
Sci Signal 2(94):pe67.
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Harrow J, Nagy A, Reymond A, Alioto T, Patthy L, Antonarakis SE, Guigó R (2009).
Identifying protein-coding genes in genomic sequences.
Genome Biol 10(1):201.
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Hausmann G, von Mering C, Basler K (2009).
The hedgehog signaling pathway: where did it come from?
PLoS Biol 7(6):e1000146.
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Hubert FX, Kinkel SA, Crewther PE, Cannon PZ, Webster KE, Link M, Uibo R, O’Bryan MK, Meager A, Forehan SP, Smyth GK, Mittaz L, Antonarakis SE, Peterson P, Heath WR, Scott HS (2009).
Aire-deficient C57BL⁄6 mice mimicking the common human 13-base pair deletion mutation present with only a mild autoimmune phenotype.
J Immunol 182(6):3902-18.
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Kessler R, Hausmann G, Basler K (2009).
The PHD domain is required to link Drosophila Pygopus to Legless/beta-catenin and not to histone H3.
Mech Dev 126(8-9):752-9.
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Le Martelot G, Claudel T, Gatfield D, Schaad O, Kornmann B, Sasso GL, Moschetta A, Schibler U (2009).
REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis.
PLoS Biol 7(9):e1000181.
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Makrythanasis P, Kapranov P, Bartoloni L, Reymond A, Deutsch S, Guigó R, Denoeud F, Drenkow J, Rossier C, Ariani F, Capra V, Excoffier L, Renieri A, Gingeras TR, Antonarakis SE (2009).
Variation in novel exons (RACEfrags) of the MECP2 gene in Rett syndrome patients and controls.
Hum Mutat 30(9):E866-79.
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Menzel O, Birraux J, Wildhaber BE, Jond C, Lasne F, Habre W, Trono D, Nguyen TH, Chardot C (2009).
Biosafety in ex vivo gene therapy and conditional ablation of lentivirally transduced hepatocytes in nonhuman primates.
Mol Ther 17(10):1754-60.
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Meylan S, Trono D (2009).
Innate immunity against retroviral pathogens: from an ambiguous genetic self to novel therapeutic approaches.
Swiss Med Wkly 139(49-50):706-11.
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Moldrich RX, Dauphinot L, Laffaire J, Vitalis T, Hérault Y, Beart PM, Rossier J, Vivien D, Gehrig C, Antonarakis SE, Lyle R, Potier MC (2009).
Proliferation deficits and gene expression dysregulation in Down’s syndrome (Ts1Cje) neural progenitor cells cultured from neurospheres.
J Neurosci Res 87(14):3143-52.
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Molnar A, Hsueh HA, Roska B, Werblin FS (2009).
Crossover inhibition in the retina: circuitry that compensates for nonlinear rectifying synaptic transmission.
J Comput Neurosci 27(3):569-90.
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Montgomery SB, Dermitzakis ET (2009).
The resolution of the genetics of gene expression.
Hum Mol Genet 18(R2):R211-5.
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Moshkin YM, Kan TW, Goodfellow H, Bezstarosti K, Maeda RK, Pilyugin M, Karch F, Bray SJ, Demmers JA, Verrijzer CP (2009).
Histone chaperones ASF1 and NAP1 differentially modulate removal of active histone marks by LID-RPD3 complexes during NOTCH silencing.
Mol Cell 35(6):782-93.
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Mosimann C, Hausmann G, Basler K (2009).
Beta-catenin hits chromatin: regulation of Wnt target gene activation.
Nat Rev Mol Cell Biol 10(4):276-86.
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Mosimann C, Hausmann G, Basler K (2009).
The role of Parafibromin⁄Hyrax as a nuclear Gli⁄Ci-interacting protein in Hedgehog target gene control.
Mech Dev 126(5-6):394-405.
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Münch TA, da Silveira RA, Siegert S, Viney TJ, Awatramani GB, Roska B (2009).
Approach sensitivity in the retina processed by a multifunctional neural circuit.
Nat Neurosci 12(10):1308-16.
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Nelis M, Esko T, Mägi R, Zimprich F, Zimprich A, Toncheva D, Karachanak S, Piskácková T, Balascák I, Peltonen L, Jakkula E, Rehnström K, Lathrop M, Heath S, Galan P, Schreiber S, Meitinger T, Pfeufer A, Wichmann HE, Melegh B, Polgár N, Toniolo D, Gasparini P, D’Adamo P, Klovins J, Nikitina-Zake L, Kucinskas V, Kasnauskiene J, Lubinski J, Debniak T, Limborska S, Khrunin A, Estivill X, Rabionet R, Marsal S, Julià A, Antonarakis SE, Deutsch S, Borel C, Attar H, Gagnebin M, Macek M, Krawczak M, Remm M, Metspalu A (2009).
Genetic structure of Europeans: a view from the North-East.
PLoS One 4(5):e5472.
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Nikolaev SI, Deutsch S, Genolet R, Borel C, Parand L, Ucla C, Schütz F, Duriaux Sail G, Dupré Y, Jaquier-Gubler P, Araud T, Conne B, Descombes P, Vassalli JD, Curran J, Antonarakis SE (2009).
Transcriptional and post-transcriptional profile of human chromosome 21.
Genome Res 19(8):1471-9.
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Nikolaev SI, Iseli C, Sharp AJ, Robyr D, Rougemont J, Gehrig C, Farinelli L, Antonarakis SE (2009).
Detection of genomic variation by selection of a 9 mb DNA region and high throughput sequencing.
PLoS One 4(8):e6659.
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Pecho-Vrieseling E, Sigrist M, Yoshida Y, Jessell TM, Arber S (2009).
Specificity of sensory-motor connections encoded by Sema3e-Plxnd1 recognition.
Nature 459(7248):842-6.
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Pereira PL, Magnol L, Sahún I, Brault V, Duchon A, Prandini P, Gruart A, Bizot JC, Chadefaux-Vekemans B, Deutsch S, Trovero F, Delgado-García JM, Antonarakis SE, Dierssen M, Herault Y (2009).
A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome.
Hum Mol Genet 18(24):4756-69.
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Pilyugin M, Demmers J, Verrijzer CP, Karch F, Moshkin YM (2009).
Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases.
PLoS One 4(12):e8328.
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Rivière S, Challet L, Fluegge D, Spehr M, Rodriguez I (2009).
Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors.
Nature 459(7246):574-7.
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Santoni de Sio FR, Trono D (2009).
APOBEC3G-depleted resting CD4+ T cells remain refractory to HIV1 infection.
PLoS One 4(8):e6571.
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Siegert S, Scherf BG, Del Punta K, Didkovsky N, Heintz N, Roska B (2009).
Genetic address book for retinal cell types.
Nat Neurosci 12(9):1197-204.
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Song H, Spichiger-Haeusermann C, Basler K (2009).
The ISWI-containing NURF complex regulates the output of the canonical Wingless pathway.
EMBO Rep 10(10):1140-6.
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Soshnikova N and Duboule D (2009).
Epigenetic regulation of vertebrate Hox genes: A dynamic equilibrium.
Epigenetics 4(8):537-40.
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Soshnikova N and Duboule D (2009).
Epigenetic temporal control of mouse Hox genes in vivo.
Science 324(5932):1320-23.
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The Bovine Genome Sequencing and Analysis Consortium, Elsik CG, Tellam RL, Worley KC (2009).
The genome sequence of taurine cattle: a window to ruminant biology and evolution.
Science 324(5926):522-8.
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Tschopp P, Tarchini B, Spitz F, Zakany J, Duboule D (2009).
Uncoupling time and space in the collinear regulation of Hox genes.
PLoS Genet 5(3):e1000398.
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2008
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Arber S (2008).
FoxP1: conducting the Hox symphony in spinal motor neurons.
Nat Neurosci 11(10):1122-4.
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Attanasio C, Reymond A, Humbert R, Lyle R, Kuehn MS, Neph S, Sabo PJ, Goldy J, Weaver M, Haydock A, Lee K, Dorschner M, Dermitzakis ET, Antonarakis SE, Stamatoyannopoulos JA (2008).
Assaying the regulatory potential of mammalian conserved non-coding sequences in human cells.
Genome Biol 9(12):R168.
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Bach D, Peddy S, Mangeat B, Lakkaraju A, Strub K, Trono D (2008).
Characterization of APOBEC3G binding to 7SL RNA.
Retrovirology 5(1):54.
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Borel C, Antonarakis SE (2008).
Functional genetic variation of human miRNAs and phenotypic consequences.
Mamm Genome 19(7-8):503-9.
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Borel C, Gagnebin M, Gehrig C, Kriventseva EV, Zdobnov EM, Antonarakis SE (2008).
Mapping of small RNAs in the human ENCODE regions.
Am J Hum Genet 82(4):971-81.
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Canzonetta C, Mulligan C, Deutsch S, Ruf S, O’Doherty A, Lyle R, Borel C, Lin-Marq N, Delom F, Groet J, Schnappauf F, De Vita S, Averill S, Priestley JV, Martin JE, Shipley J, Denyer G, Epstein CJ, Fillat C, Estivill X, Tybulewicz VL, Fisher EM, Antonarakis SE, Nizetic D (2008).
DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome.
Am J Hum Genet 83(3):388-400.
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Dalla Torre di Sanguinetto SA, Dasen JS, Arber S (2008).
Transcriptional mechanisms controlling motor neuron diversity and connectivity.
Curr Opin Neurobiol 18(1):36-43.
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Dermitzakis ET (2008).
From gene expression to disease risk.
Nat Genet 40(5):492-3.
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Djebali S, Kapranov P, Foissac S, Lagarde J, Reymond A, Ucla C, Wyss C, Drenkow J, Dumais E, Murray RR, Lin C, Szeto D, Denoeud F, Calvo M, Frankish A, Harrow J, Makrythanasis P, Vidal M, Salehi-Ashtiani K, Antonarakis SE, Gingeras TR, Guigó R (2008).
Efficient targeted transcript discovery via array-based normalization of RACE libraries.
Nat Methods 5(7):629-35.
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Friedli M, Nikolaev S, Lyle R, Arcangeli M, Duboule D, Spitz F, Antonarakis SE (2008).
Characterization of mouse Dactylaplasia mutations: a model for human ectrodactyly SHFM3.
Mamm Genome 19(4):272-8.
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Fokstuen S, Lyle R, Munoz A, Gehrig C, Lerch R, Perrot A, Osterziel KJ, Geier C, Beghetti M, Mach F, Sztajzel J, Sigwart U, Antonarakis SE, Blouin JL (2008).
A DNA resequencing array for pathogenic mutation detection in hypertrophic cardiomyopathy.
Hum Mutat 29(6):879-85.
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Guipponi M, Antonarakis SE, Scott HS (2008).
TMPRSS3, a type II transmembrane serine protease mutated in non-syndromic autosomal recessive deafness.
Front Biosci 13:1557-67.
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Hoda JC, Gu W, Friedli M, Phillips HA, Bertrand S, SE Antonarakis SE, Goudie D, Roberts R, Scheffer IE, Marini C, Patel J, Berkovic SF, Mulley JC, Steinlein OK, Bertrand D (2008).
Human nocturnal frontal lobe epilepsy: pharmocogenomic profiles of pathogenic nicotinic acetylcholine receptor beta-subunit mutations outside the ion channel pore.
Mol Pharmacol 74(2):379-91.
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Jakobsson J, Cordero MI, Bisaz R, Groner AC, Busskamp V, Bensadoun JC, Cammas F, Losson R, Mansuy IM, Sandi C, Trono D (2008).
KAP1-mediated epigenetic repression in the forebrain modulates behavioral vulnerability to stress.
Neuron 60(5):818-31.
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Lagali PS, Balya D, Awatramani GB, Münch TA, Kim DS, Busskamp V, Cepko CL, Roska B (2008).
Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration.
Nat Neurosci 11(6):667-75.
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Loeuillet C, Deutsch S, Ciuffi A, Robyr D, Taffé P, Muñoz M, Beckmann JS, Antonarakis SE, Telenti A (2008).
In vitro whole-genome analysis identifies a susceptibility locus for HIV-1.
PLoS Biol 6(2):e32.
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Montavon T, Le Garrec J-F, Kerszberg M, Duboule D (2008).
Modeling Hox gene regulation in digits: reverse collinearity and the molecular origin of thumbness.
Genes Dev 22(3):346-59.
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Mukhopadhyay A, Deplancke B, Walhout AJ, Tissenbaum HA (2008).
Chromatin immunoprecipitation (ChIP) coupled to detection by quantitative real-time PCR to study transcription factor binding to DNA in Caenorhabditis elegans.
Nat Protoc 3(4):698-709.
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Reinke H, Saini C, Fleury-Olela F, Dibner V, Schibler U (2008).
Differencial display of DNA-Binding proteins reveals heat-shock factor 1 as a circadian transcription factor.
Genes Dev 22(3):331-45.
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Sauvain MO, Dorr AP, Stevenson B, Quazzola A, Naef F, Wiznerowicz M, Schütz F, Jongeneel V, Duboule D, Spitz F, Trono D (2008).
Genotypic features of lentivirus transgenic mice.
J Virol 82(14):7111-9.
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Schwank G, Restrepo S, Basler K (2008).
Growth regulation by Dpp: an essential role for Brinker and a non-essential role for graded signaling levels.
Development 135(24):4003-13.
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| |
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Stepien AE, Arber S (2008).
Probing the locomotor conundrum: Descending the ’V’ interneuron ladder.
Neuron 60(1):1-4.
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| |
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Voronov SV, Frere SG, Giovedi S, Pollina EA, Borel C, Zhang H, Schmidt C, Akeson EC, Wenk MR, Cimasoni L, Arancio O, Davisson MT, Antonarakis SE, Gardiner K, De Camilli P, Di Paolo G (2008).
Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down’s syndrome.
Proc Natl Acad Sci USA 105(27):9415-20.
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| |
2010
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Ait-Lounis A, Bonal C, Seguín-Estévez Q, Schmid CD, Bucher P, Herrera PL, Durand B, Meda P, Reith W (2010).
The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression.
Diabetes 59(7):1674-85.
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| |
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Canella D, Praz V, Reina JH, Cousin P, Hernandez N (2010).
Defining the RNA polymerase III transcriptome: genome-wide localization of the RNA polymerase III transcription machinery in human cells.
Genome Res 20(6):710-21.
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| |
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Cederroth CR, Auger J, Zimmermann C, Eustache F, Nef S (2010).
Soy, phyto-oestrogens and male reproductive function: a review.
Int J Androl 33(2):304-16.
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| |
|
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Cederroth CR, Zimmermann C, Beny JL, Schaad O, Combepine C, Descombes P, Doerge DR, Pralong FP, Vassalli JD, Nef S (2010).
Potential detrimental effects of a phytoestrogen-rich diet on male fertility in mice.
Mol Cell Endocrinol 321(2):152-60.
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| |
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Cornu M, Modi H, Kawamori D, Kulkarni RN, Joffraud M, Thorens B (2010).
Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression.
J Biol Chem 285(14):10538-45.
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| |
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Dibner C, Schibler U, Albrecht U (2010).
The mammalian circadian timing system: organization and coordination of central and peripheral clocks.
Annu Rev Physiol 72:517-49.
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| |
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Dupont J, Musnier A, Decourtye J, Boulo T, Lécureuil C, Guillou H, Valet S, Fouchécourt S, Pitetti JL, Nef S, Reiter E, Crépieux P (2010).
FSH-stimulated PTEN activity accounts for the lack of FSH mitogenic effect in prepubertal rat Sertoli cells.
Mol Cell Endocrinol 315(1-2):271-6.
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Gu C, Stein GH, Pan N, Goebbels S, Hörnberg H, Nave KA, Herrera P, White P, Kaestner KH, Sussel L, Lee JE (2010).
Pancreatic beta cells require NeuroD to achieve and maintain functional maturity.
Cell Metab 11(4):298-310.
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| |
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Lei H, Poitry-Yamate C, Preitner F, Thorens B, Gruetter R (2010).
Neurochemical profile of the mouse hypothalamus using in vivo (1)H MRS at 14.1T.
NMR Biomed 23(6):578-83.
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| |
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Leuenberger N, Wahli W (2010).
PPARα, a key regulator of hepatic energy homeostasis in health and disease.
In Signaling Pathways in Liver Diseases, 2nd ed., Eds J-F Dufour and P-A Clavien, Springer Berlin Heidelberg, pp. 305-315.
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Michels AA, Robitaille AM, Buczynski-Ruchonnet D, Hodroj W, Reina JH, Hall MN, Hernandez N (2010).
mTORC1 directly phosphorylates and regulates human MAF1.
Mol Cell Biol 30(15):3749-57.
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| |
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Morf J, Schibler U (2010).
Circadian cell-cycle progression: cracking open the gate.
Cell 140(4):458-9.
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Morgan H, Beck T, Blake A, Gates H, Adams N, Debouzy G, Leblanc S, Lengger C, Maier H, Melvin D, Meziane H, Richardson D, Wells S, White J, Wood J, EUMODIC Consortium, de Angelis MH, Brown SD, Hancock JM, Mallon AM (2010).
EuroPhenome: a repository for high-throughput mouse phenotyping data.
Nucleic Acids Res 38(Database issue):D577-85.
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Mounien L, Marty N, Tarussio D, Metref S, Genoux D, Preitner F, Foretz M, Thorens B (2010).
Glut2-dependent glucose-sensing controls thermoregulation by enhancing the leptin sensitivity of NPY and POMC neurons.
FASEB J 24(6):1747-58.
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Papaioannou MD, Lagarrigue M, Vejnar CE, Rolland AD, Kühne F, Aubry F, Schaad O, Fort A, Descombes P, Neerman-Arbez M, Guillou F, Zdobnov EM, Pineau C, Nef S (2010).
Loss of Dicer in Sertoli cells has a major impact on the testicular proteome of mice.
Mol Cell Proteomics. E-pub ahead of print.
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| |
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Papaioannou MD, Nef S (2010).
microRNAs in the testis: building up male fertility.
J Androl 31(1):26-33.
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| |
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Rotman N, Wahli W (2010).
PPAR modulation of kinase-linked receptor signaling in physiology and disease.
Physiology (Bethesda) 25(3):176-85.
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| |
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So A, Thorens B (2010).
Uric acid transport and disease.
J Clin Invest 120(6):1791-9.
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| |
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Thorens B, Mueckler MM (2010).
Glucose transporters in the 21st Century.
Am J Physiol Endocrinol Metab 298: E141-E145.
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Vegiopoulos A, Müller-Decker K, Strzoda D, Schmitt I, Chichelnitskiy E, Ostertag A, Diaz MB, Rozman J, Hrabe de Angelis M, Nüsing RM, Meyer CW, Wahli W, Klingenspor M, Herzig S (2010).
Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes.
Science 328(5982):1158-6.
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| |
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Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J (2010).
Thioredoxin-interacting protein links oxidative stress to inflammasome activation.
Nat Immunol 11(2):136-40.
|
| |
2009
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|
Bibert S, Hess SK, Firsov D, Thorens B, Geering K, Horisberger JD, Bonny O (2009).
Mouse GLUT9: evidences for a urate uniporter.
Am J Physiol Renal Physiol 297(3):F612-9.
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| |
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|
Bonal C, Thorel F, Ait-Lounis A, Reith W, Trumpp A, Herrera PL (2009).
Pancreatic inactivation of c-Myc decreases acinar mass and transdifferentiates acinar cells into adipocytes in mice.
Gastroenterology 136(1):309-19.
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| |
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Cantley J, Selman C, Shukla D, Abramov AY, Forstreuter F, Esteban MA, Claret M, Lingard SJ, Clements M, Harten SK, Asare-Anane H, Batterham RL, Herrera PL, Persaud SJ, Duchen M, Maxwell PH, Withers DJ (2009).
Deletion of the von Hippel-Lindau gene in pancreatic beta-cells impairs glucose homeostasis in mice.
J Clin Invest 119(1):125-35.
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| |
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Cederroth CR, Nef S (2009).
Fetal programming of adult glucose homeostasis in mice.
PLoS One 4(9):e7281.
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| |
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Cederroth CR, Nef S (2009).
Soy, phytoestrogens and metabolism: a review.
Mol Cell Endocrinol 304(1-2):30-42.
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| |
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Chong HC, Tan MJ, Philippe V, Tan SH, Tan CK, Ku CW, Goh YY, Wahli W, Michalik L, Tan NS (2009).
Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta⁄delta is essential for skin homeostasis and wound healing.
J Cell Biol 184(6):817-31.
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| |
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Cornu M, Yang JY, Jaccard E, Poussin C, Widmann C, Thorens B (2009).
Glucagon-like peptide-1 protects beta-cells against apoptosis by increasing the activity of an IGF-2⁄IGF-1 receptor autocrine loop.
Diabetes 58(8):1816-25.
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| |
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Demers A, Caron V, Rodrigue-Way A, Wahli W, Ong H, Tremblay A (2009).
A concerted kinase interplay identifies PPARgamma as a molecular target of ghrelin signaling in macrophages.
PLoS One 4(11):e7728.
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| |
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Desgraz R, Herrera PL (2009).
Pancreatic neurogenin 3-expressing cells are unipotent islet precursors.
Development 136(21):3567-74.
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| |
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Dibner C, Sage D, Unser M, Bauer C, d’Eysmond T, Naef F, Schibler U (2009).
Circadian gene expression is resilient to large fluctuations in overall transcription rates.
EMBO J 28(2):123-34.
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Isken F, Weickert MO, Tschöp MH, Nogueiras R, Möhlig M, Abdelrahman A, Klaus S, Thorens B, Pfeiffer AF (2009).
Metabolic effects of diets differing in glycaemic index depend on age and endogenous glucose-dependent insulinotrophic polypeptide in mice.
Diabetologia 52(10):2159-68.
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Leuenberger N, Pradervand S, Wahli W (2009).
Sumoylated PPARalpha mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice.
J Clin Invest 119(10):3138-48.
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Lohmann C, Schäfer N, von Lukowicz T, Sokrates Stein MA, Borén J, Rütti S, Wahli W, Donath MY, Lüscher TF, Matter CM (2009).
Atherosclerotic mice exhibit systemic inflammation in periadventitial and visceral adipose tissue, liver, and pancreatic islets.
Atherosclerosis 207(2):360-7.
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| |
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Nef S, Vassalli JD (2009).
Complementary pathways in mammalian female sex determination.
J Biol 8(8):74.
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| |
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Papaioannou MD, Pitetti JL, Ro S, Park C, Aubry F, Schaad O, Vejnar CE, Kühne F, Descombes P, Zdobnov EM, McManus MT, Guillou F, Harfe BD, Yan W, Jégou B, Nef S (2009).
Sertoli cell Dicer is essential for spermatogenesis in mice.
Dev Biol 326(1):250-9.
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| |
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Pétremand J, Bulat N, Butty AC, Poussin C, Rütti S, Au K, Ghosh S, Mooser V, Thorens B, Yang JY, Widmann C, Waeber G (2009).
Involvement of 4E-BP1 in the protection induced by HDLs on pancreatic beta-cells.
Mol Endocrinol 23(10):1572-86.
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| |
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Pitetti JL, Torre D, Conne B, Papaioannou MD, Cederroth CR, Xuan S, Kahn R, Parada LF, Vassalli JD, Efstratiadis A, Nef S (2009).
Insulin receptor and IGF1R are not required for oocyte growth, differentiation, and maturation in mice.
Sex Dev 3(5):264-72.
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| |
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Preitner F, Bonny O, Laverrière A, Rotman S, Firsov D, Da Costa A, Metref S, Thorens B (2009).
Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy.
Proc Natl Acad Sci USA 106(36):15501-6.
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| |
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Rotman N, Wahli W (2009).
Fatty acid synthesis and PPARalpha hand in hand.
Chem Biol 16(8):801-2.
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| |
|
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Silva JP, von Meyenn F, Howell J, Thorens B, Wolfrum C, Stoffel M (2009).
Regulation of adaptive behaviour during fasting by hypothalamic Foxa2.
Nature 462(7273):646-50.
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| |
|
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Somm E, Schwitzgebel VM, Toulotte A, Cederroth CR, Combescure C, Nef S, Aubert ML, Hüppi PS (2009).
Perinatal exposure to bisphenol a alters early adipogenesis in the rat.
Environ Health Perspect 117(10):1549-55.
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| |
|
|
Suter DM, Schibler U (2009).
Physiology. Feeding the clock.
Science 326(5951):378-9.
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| |
|
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Swetloff A, Conne B, Huarte J, Pitetti JL, Nef S, Vassalli JD (2009).
Dcp1-bodies in mouse oocytes.
Mol Biol Cell 20(23):4951-61.
|
| |
|
|
Wahli W, Constantin N (2009).
La nutrigénomique, nouvelle alliée de la santé.
Forum Med Suisse 9(11):224-227.
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Wahli W, Constantin N (2009).
La nutrigénomique, un defi médico-socio-économique.
Forum Med Suisse 9(12):242-245.
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| |
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|
Yang JY, Walicki J, Jaccard E, Dubuis G, Bulat N, Hornung JP, Thorens B, Widmann C (2009).
Expression of the NH(2)-terminal fragment of RasGAP in pancreatic beta-cells increases their resistance to stresses and protects mice from diabetes.
Diabetes 58(11):2596-606.
|
| |
2008
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|
Alonso-Magdalena P, Ropero AB, Carrera P, Cederroth CR, Baquié M, Gauthier BR, Nef S, Stefani E, Nadal A (2008).
Pancreatic insulin content regulation by the estrogen receptor ER alpha.
PLoS ONE 3(4):e2069.
|
| |
|
|
Asher A, Gatfield D, Stratmann M, Reinke H, Kreppel F, Mostoslavsky R, Alt FW, Schibler U (2008).
SIRT1 regulates circadian clock gene expression through PER2 deacetylation.
Cell 134(2):317-28.
|
| |
|
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Brawand D, Wahli W, Kaessmann H (2008).
Loss of egg yolk genes in mammals and the origin of lactation and placentation.
PLoS Biol 6(3):e63.
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| |
|
|
Dostert C, Pétrilli V, Van Bruggen R, Steele C, Mossman BT, Tschopp J (2008).
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica.
Science 320(5876):674-7.
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| |
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Gatfield D, Schibler U (2008).
Circadian glucose homeostasis requires compensatory interference between brain and liver clocks.
Proc Nat Acad Sci USA 105(39):14753-4.
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Klinger S, Poussin C, Debril MB, Dolci W, Halban PA, Thorens B (2008).
Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14.
Diabetes 57(3):584-93.
|
| |
|
|
Klinger S, Thorens B (2008).
Molecular biology of gluco-incretin function.
In: Pancreatic beta-cell in health and disease. S. Seino and G.I. Bell, Eds. Springer, pp.315-334.
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Minehira K, Young SG, Villanueva CJ, Yetukuri L, Oresic M, Hellerstein MK, Farese RV Jr, Horton JD, Preitner F, Thorens B, Tappy L (2008).
Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice.
J Lipid Res 49(9):2038-44.
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| |
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Reinke H, Saini C, Fleury-Olela F, Dibner V, Schibler U (2008).
Differencial display of DNA-Binding proteins reveals heat-shock factor 1 as a circadian transcription factor.
Genes Dev 22(3):331-45.
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| |
|
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Shanmugam M, Hernandez N (2008).
Mitotic functions for SNAP45, a subunit of the small nuclear RNA activating protein complex SNAPc.
J Biol Chem 283(21):14845-56.
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| |
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|
Troy S, Soty M, Ribeiro L, Laval L, Migrenne S, Fioramonti X, Pillot B, Fauveau F, Aubert R, Viollet B, Foretz M, Leclerc J, Auchampt A, Zitoun C, Thorens B, Magnan C, Mithieux G, Andreelli F (2008).
Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice.
Cell Metab 2008 8(3):201-11.
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2010
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|
Abreu E, Aritonovska E, Reichenbach P, Cristofari G, Culp B, Terns RM, Lingner J, Terns MP (2010).
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo.
Mol Cell Biol 30(12):2971-82.
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| |
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Dieppois G, Stutz F (2010).
Connecting the transcription site to the nuclear pore: a multi-tether process that regulates gene expression.
J Cell Sci 123(Pt 12):1989-99.
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| |
|
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Dion V, Shimada K, Gasser SM (2010).
Actin-related proteins in the nucleus: life beyond chromatin remodelers.
Curr Opin Cell Biol. E-pub ahead of print.
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| |
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Ebrahimi H, Robertson ED, Taddei A, Gasser SM, Donaldson AD, Hiraga S (2010).
Early initiation of a replication origin tethered at the nuclear periphery.
J Cell Sci 123(Pt 7):1015-9.
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| |
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Feuerhahn S, Iglesias N, Panza A, Porro A, Lingner J (2010).
TERRA biogenesis, turnover and implications for function.
FEBS Lett. E-pub ahead of print.
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| |
|
|
Meister P, Towbin BD, Pike BL, Ponti A, Gasser SM (2010).
The spatial dynamics of tissue-specific promoters during C. elegans development.
Genes Dev 24(8):766-82.
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| |
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Preti M, Ribeyre C, Pascali C, Bosio MC, Cortelazzi B, Rougemont J, Guarnera E, Naef F, Shore D, Dieci G (2010).
The telomere-binding protein Tbf1 demarcates snoRNA gene promoters in Saccharomyces cerevisiae.
Mol Cell 38(4):614-20.
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| |
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Schleker T, Shimada K, Sack R, Pike BL, Gasser SM (2010).
Cell cycle-dependent phosphorylation of Rad53 kinase by Cdc5 and Cdc28 modulates checkpoint adaptation.
Cell Cycle 9(2):350-63.
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| |
|
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Taddei A, Schober H, Gasser SM (2010).
The budding yeast nucleus.
Cold Spring Harb Perspect Biol 2(8):a000612.
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| |
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Varela E, Schlecht U, Moina A, Fackenthal JD, Washburn BK, Niederhauser-Widerkehr C, Tsai-Pflugfelder M, Primig M, Gasser SM, Esposito RE (2010).
Mitotic expression of Spo13 alters M-phase progression and nucleolar localization of Cdc14 in budding yeast.
Genetics. E-pub ahead of print.
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| |
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Yoshida T, Shimada K, Oma Y, Kalck V, Akimura K, Taddei A, Iwahashi H, Kugou K, Ohta K, Gasser SM, Harata M (2010).
Actin-related protein Arp6 influences H2A.Z-dependent and -independent gene expression and links ribosomal protein genes to nuclear pores.
PLoS Genet 6(4):e1000910.
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| |
2009
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Binda M, Péli-Gulli MP, Bonfils G, Panchaud N, Urban J, Sturgill TW, Loewith R, De Virgilio C (2009).
The Vam6 GEF controls TORC1 by activating the EGO complex.
Mol Cell 35(5):563-73.
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| |
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Bühler M, Gasser SM (2009).
Silent chromatin at the middle and ends: lessons from yeasts.
EMBO J 28(15):2149-61.
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Bystricky K, Van Attikum H, Montiel MD, Dion V, Gehlen L, Gasser SM (2009).
Regulation of nuclear positioning and dynamics of the silent mating type loci by the yeast Ku70⁄Ku80 complex.
Mol Cell Biol 29(3):835-48.
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| |
|
|
Camblong J, Beyrouthy N, Guffanti E, Schlaepfer G, Steinmetz LM, Stutz F (2009).
Trans-acting antisense RNAs mediate transcriptional gene cosuppression in S. cerevisiae.
Genes Dev 23(13):1534-45.
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Chang M, Luke B, Kraft C, Li Z, Peter M, Lingner J, Rothstein R (2009).
Telomerase is essential to alleviate pif1-induced replication stress at telomeres.
Genetics 183(3):779-91.
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| |
|
|
Dion V, Wilson JH (2009).
Instability and chromatin structure of expanded trinucleotide repeats.
Trends Genet 25(7):288-97.
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Gasser SM (2009).
The shape of heredity.
Scientist 23(7):34-9.
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Hosiner D, Lempiäinen H, Reiter W, Urban J, Loewith R, Ammerer G, Schweyen R, Shore D, Schüller C (2009).
Arsenic toxicity to Saccharomyces cerevisiae is a consequence of inhibition of the TORC1 kinase combined with a chronic stress response.
Mol Biol Cell 20(3):1048-57.
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Huber A, Bodenmiller B, Uotila A, Stahl M, Wanka S, Gerrits B, Aebersold R, Loewith R (2009).
Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis.
Genes Dev 23(16):1929-43.
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Iglesias N, Lingner J (2009).
Related mechanisms for end processing at telomeres and DNA double-strand breaks.
Mol Cell 35(2):137-8.
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| |
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Lempiäinen H, Shore D (2009).
Growth control and ribosome biogenesis.
Curr Opin Cell Biol 21(6):855-63.
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|
|
Lempiäinen H, Uotila A, Urban J, Dohnal I, Ammerer G, Loewith R, Shore D (2009).
Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling.
Mol Cell 33(6):704-16.
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| |
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Luke B, Lingner J (2009).
TERRA: telomeric repeat-containing RNA.
EMBO J 28(17):2503-10.
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| |
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Martino F, Kueng S, Robinson P, Tsai-Pflugfelder M, van Leeuwen F, Ziegler M, Cubizolles F, Cockell MM, Rhodes D, Gasser SM (2009).
Reconstitution of yeast silent chromatin: multiple contact sites and O-AADPR binding load SIR complexes onto nucleosomes in vitro.
Mol Cell 33(3):323-34.
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| |
|
|
Schleker T, Nagai S, Gasser SM (2009).
Posttranslational modifications of repair factors and histones in the cellular response to stalled replication forks.
DNA Repair (Amst) 8(9):1089-100.
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| |
|
|
Schober H, Ferreira H, Kalck V, Gehlen LR, Gasser SM (2009).
Yeast telomerase and the SUN domain protein Mps3 anchor telomeres and repress subtelomeric recombination.
Genes Dev 23(8):928-38.
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| |
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Shore D, Bianchi A (2009).
Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase.
EMBO J 28(16):2309-22.
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| |
|
|
Taddei A, Van Houwe G, Nagai S, Erb I, van Nimwegen E, Gasser SM (2009).
The functional importance of telomere clustering: global changes in gene expression result from SIR factor dispersion.
Genome Res 19(4):611-25.
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| |
|
|
Varela E, Shimada K, Laroche T, Leroy D, Gasser SM (2009).
Lte1, Cdc14 and MEN-controlled Cdk inactivation in yeast coordinate rDNA decompaction with late telophase progression.
EMBO J 28(11):1562-75.
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| |
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Xu Z, Wei W, Gagneur J, Perocchi F, Clauder-Münster S, Camblong J, Guffanti E, Stutz F, Huber W, Steinmetz LM (2009).
Bidirectional promoters generate pervasive transcription in yeast.
Nature 457(7232):1033-7.
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| |
2008
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|
Haruki H, Nishikawa J, Laemmli UK (2008).
The anchor-away technique: rapid, conditional establishment of yeast mutant phenotypes.
Mol Cell 31(6):925-32.
|
| |
|
|
Luke B, Panza A, Redon S, Iglesias N, Li Z, Lingner J (2008).
The Rat1p 5’ to 3’ exonuclease degrades telomeric repeat-containing RNA and promotes telomere elongation in Saccharomyces cerevisiae.
Mol Cell 32(4):465-77.
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| |
|
|
Nagai S, Dubrana K, Tsai-Pflugfelder M, Davidson MB, Roberts TM, Brown GW, Varela E, Hediger F, Gasser SM, Krogan NJ (2008).
Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent Ubiquitin ligase.
Science 322(5901):597-602.
|
| |
|
|
Puglisi A, Bianchi A, Lemmens L, Damay P, Shore D (2008).
Distinct roles for yeast Stn1 in telomore capping and telemorease inhibition.
EMBO J 27(17):2328-39.
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| |
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Rougemaille M, Dieppois G, Kisseleva-Romanova E, Gudipati RK, Lemoine S, Blugeon C, Boulay J, Jensen TH, Stutz F, Devaux F, Libri D (2008).
THO⁄Sub2p functions to coordinate 3’-end processing with gene-nuclear pore association.
Cell 135(2):308-21.
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| Pilot project - Ended in June 2010 |
›› Top |
2010
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Galliot B, Chera S (2010).
The Hydra model: disclosing an apoptosis-driven generator of Wnt-based regeneration.
Trends Cell Biol. E-pub ahead of print.
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Galliot B, Ghila L (2010).
Cell plasticity in homeostasis and regeneration.
Mol Reprod Dev. E-pub ahead of print.
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Stecca B, Ruiz I Altaba A (2010).
Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals.
J Mol Cell Biol 2(2):84-95.
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